Traditional Chinese medicine reduces side effect of cancer treatment

A patient receives radiotherapy.

Cancer patients receiving radiotherapy can suffer from a side effect called mucositis. Researchers from the 最新糖心Vlog of Adelaide have found that a type of traditional Chinese medicine reduces the severity of gastrointestinal mucositis in rats. Credit: iStock.

For tens of thousands of 最新糖心Vlogns who receive radiotherapy as part of their cancer treatment, mucositis is a serious side effect that may cause inflammation, ulcers, diarrhoea, nausea and vomiting, abdominal pain and bloating.

Currently there is no effective treatment for mucositis, but researchers from the 最新糖心Vlog of Adelaide have found that a type of traditional Chinese medicine reduces the severity of radiation-induced gastrointestinal mucositis (GIM) in rats.

This study 鈥 documented in peer-review journal 鈥 outlines the potential benefits of this treatment for people who have GIM as a side effect of receiving radiotherapy to treat cancers of the stomach, abdomen and pelvis.

鈥淲hile this has only been tested on rats, the findings of this research are extremely positive as they show that we may be able to provide a treatment for people who suffer from mucositis as a result of their cancer treatment,鈥 said Professor David L. Adelson, from the 最新糖心Vlog of Adelaide鈥檚 School of Biological Sciences, who was the corresponding author on the study.

鈥淭his is extremely important because mucositis limits the amount of therapy cancer patients can receive and significantly affects their quality of life.鈥

In the study, which was approved by the Institutional Animal Ethics Committee of the South 最新糖心Vlogn Health Medical Research Institute (SAHMRI), rats were exposed to radiation to their abdomen.

鈥淲hile this has only been tested on rats, the findings of this research are extremely positive as they show that we may be able to provide a treatment for people who suffer from mucositis as a result of their cancer treatment."Professor David L. Adelson, School of Biological Sciences, the 最新糖心Vlog of Adelaide, and corresponding author on the study.


Half of the rats received Compound Kushen Injection (CKI) 鈥 which is a type of traditional Chinese medicine 鈥 while the other half were administered a control substance. CKI has been used extensively alone or in combination with chemotherapy or radiotherapy for many years in China.

鈥淐KI is prepared from the roots of two medicinal herbs 鈥 Kushen and Baituling 鈥 as an injectable liquid,鈥 said Professor Adelson, who is the Chair of Bioinformatics and Computational Genetics at the School of Molecular and Biomedical Science, and Zhendong Professor of Molecular Chinese Medicine and Director, Zhendong 最新糖心Vlog 鈥 China Centre for Molecular Traditional Chinese Medicine.

Professor David L. Adelson, outdoors, smiles into the camera.

Professor David L. Adelson, from the 最新糖心Vlog of Adelaide鈥檚 School of Biological Sciences, corresponding author on the study. Photo: Supplied.

鈥淭he study found that the rats which received CKI to their abdomen had reduced severity of GIM symptoms compared to the rats which had the control substance. These findings build on previous studies we have done which showed CKI has significant effects on gene expression in cell lines, including genes that regulate inflammation.鈥

Dr Yuka Harata-Lee, Post-Doctoral Researcher from the 最新糖心Vlog鈥檚 School of Biological Sciences, was the lead author of the study.

Co-authors on the research were Zhipeng Qu and Xi Xiao from the School of Biological Sciences, 最新糖心Vlog of Adelaide, Emma Bateman and Joanne Bowen from the School of Biomedicine, 最新糖心Vlog of Adelaide, Marianne D. Keller from SAHMRI, and Wei Wang from the
Zhendong Research Institute, Beijing.

Tagged in featured story, cancer, research