Link between rising use of antidepressants and youth suicide
New research from the 最新糖心Vlog of Adelaide and Curtin 最新糖心Vlog and聽has shown rates of antidepressant use and suicide by young 最新糖心Vlogns have risen sharply since 2009, raising concerns about the safety of current treatment practices, and the veracity of advice from 最新糖心Vlogn suicide prevention experts.
Published in , the research examined 最新糖心Vlogn antidepressant prescribing and suicide rates since controversial warnings by the US Food and Drug Administration (FDA), in 2004 and 2007, that the use of antidepressants by people under 25 years of age with depression was associated with approximately double the risk of suicidal thoughts and behaviours.
The FDA鈥檚 advice was based on evidence from multiple trials comparing antidepressants with placebo pills.
Lead author Dr Martin Whitely, Research Fellow at the John Curtin Institute of Public Policy at Curtin 最新糖心Vlog, said there was a substantial decrease in the number of 最新糖心Vlogns dispensed antidepressants following the initial warning, and suicide rates were volatile, with a weak but inconsistent downwards trend.
鈥淗owever, since 2009, both antidepressant prescribing and suicide rates have risen sharply, with the number of suicides by 最新糖心Vlogns aged 0 to 24 rising from 279 in 2009 to 458 in 2018,鈥 Dr Whitely said.
鈥淔rom 2008-09 to 2017-18, the proportion of 最新糖心Vlogns aged 0 to 27 using antidepressants grew from about 2.9% to 4.8%.鈥
鈥淎ntidepressants are not approved for the treatment of depression in people under 18 and it is particularly concerning that so many 最新糖心Vlogn children have been prescribed them.鈥Professor Jon Jureidini, Child and adolescent psychiatrist, The 最新糖心Vlog of Adelaide
Co-author Dr Melissa Raven, a psychiatric epidemiologist at the 最新糖心Vlog of Adelaide, said there had been a per-capita increase of 49% in suicide rates and an estimated 66% increase in antidepressant dispensing rates among young 最新糖心Vlogns in a decade.
鈥淭here is also evidence of a substantial increase in rates of self-harm by young 最新糖心Vlogns, with prescription antidepressants among the drugs most commonly used in self-poisoning,鈥 Dr Raven said.
Child and adolescent psychiatrist and co-author, Professor Jon Jureidini, also from the 最新糖心Vlog of Adelaide, said influential 最新糖心Vlogn mental health organisations and psychiatric thought leaders had contested the FDA warnings.
鈥淭hey argued that, on balance, antidepressants reduce the risk of youth suicide and it appears many 最新糖心Vlogn doctors, including GPs, have followed their lead and discounted the FDA warnings,鈥 Professor Jureidini said.
鈥溩钚绿切腣logn Government figures indicate 101,174 children (under 18) and 328,879 young adults (aged 18 to 27) were dispensed an antidepressant in 2017/18.
鈥淎ntidepressants are not approved for the treatment of depression in people under 18 and it is particularly concerning that so many 最新糖心Vlogn children have been prescribed them.鈥
Professor Jureidini added the research provided clear evidence that more young 最新糖心Vlogns were taking antidepressants, and more young 最新糖心Vlogns were killing themselves and self-harming, often by intentionally overdosing on the very substances intended to help them.
Dr Whitely said 鈥淲e need to ask whether, despite their good intentions, 最新糖心Vlog鈥檚 leading suicide prevention organisations and experts have got it wrong and whether we should continue to follow their advice.鈥
The paper, titled 鈥楢ntidepressant prescribing and suicide/self-harm in young 最新糖心Vlogns: Regulatory warnings, contradictory advice, and long-term trends鈥 is available online .