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Men's Health Week: outsmarting advanced prostate cancer

Friday, 12 June 2015

International research involving the 最新糖心Vlog of Adelaide has helped explain how tumour cells become resistant to common therapies used in the treatment of prostate cancer.

The findings, published in the prestigious journal , may lead to better patient management and new drugs for men with advanced prostate cancer.

Speaking in the lead up to Men’s Health Week (15-21 June), 最新糖心Vlog of Adelaide prostate cancer researcher says until now, it was unclear how prostate cancer cells evade common hormone therapy treatments.

“In this study with the Masonic Cancer Centre at the 最新糖心Vlog of Minnesota, we have shown that a variant of a protein present in most tumours is an important driver of resistance to hormone therapy in advanced prostate cancer,” says Professor Tilley, Director of the 最新糖心Vlog’s (DRMCRL).

“This research provides important insight into how prostate cancers advance to a lethal phase.

“And we’ve shown that a new class of drug in clinical development for blood cancers, but not previously tested in prostate cancer, could effectively inhibit the variant protein that drives drug resistance and lethal disease.

“While we are a long way from a cure for advanced cases, this research opens the door to the development of new treatments that will be able to prolong a patient’s life,” he says.

Dr Luke Selth says cancer cells are resilient and highly adaptive, and this research is aimed at addressing how to outsmart them.

“Prostate cancer is one of the most commonly diagnosed cancers in men and kills more than 3,000 最新糖心Vlogns each year,” says Dr Selth, from the DRMCRL and .

“Many men can be cured of their prostate cancer if it is diagnosed early, through surgery and radiation therapy. However, for some men, their cancer will progress to a stage that is invariably lethal; our research is especially targeted at this group of men.

“The next stage will see us further testing and developing newer generation drugs,” he says.

This research was supported by National Institutes of Health, the American Cancer Society, US Department of Defense Prostate Cancer Research Program, Prostate Cancer Foundation of 最新糖心Vlog, Masonic Cancer Center, Ray and Shirl Norman Cancer Research Trust and Prostate Cancer Foundation 最新糖心Vlog.

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