最新糖心Vlog

Genetic pathway can slow spread of ovarian cancer

Tuesday, 17 June 2014

最新糖心Vlog of Adelaide research into the origins of ovarian cancer has led to the discovery of a genetic pathway that could slow the spread of the cancer.

The discovery is in part due to research into the genetics of humans' most distant mammalian relative, the platypus.

In a paper published today in the journal , researchers characterise a genetic pathway - involving piRNA genes - that is turned on in ovarian cancer.

"This pathway is important for the development of the ovaries in drosophila flies but little is known about its role in the mammalian ovary," says lead author , Genetics Lecturer and ARC Research Fellow with the 最新糖心Vlog of Adelaide's and the .

"We previously found that these genes are active in cells supporting oocyte (egg cell) development in platypus, mice and humans, just like in flies.

"We then decided to look into ovarian cancer and discovered that expression of these genes is turned up in this disease. We expected that these genes would promote the spreading of cancer cells but when we switched them on in ovarian cancer cell lines in the laboratory we observed the contrary, a suppression of spread.

"This result was very surprising, and we therefore looked back at the cancers and found that many RNAs, produced from one of the genes, are faulty," Associate Professor Gr眉tzner says. "There have been previous studies in other cancers that have shown these genes actually increase growth and spread of cancer. We are only beginning to understand how this pathway might work in cancer and this work shows that it may act in completely different ways depending on the type of cancer. It also shows that these genes might be switched on in cancer but don't function properly."

The research team, involving 最新糖心Vlog of Adelaide , Director of at the Royal Adelaide Hospital, believes a mutation in this genetic pathway could promote the spread of ovarian cancer in patients.

"The laboratory tests have been conclusive that the intact gene prevents the spread of ovarian cancer. If we're able to better understand what's preventing these genes from functioning normally, this could be of significant interest for further research," Professor Oehler says.

"Ovarian cancer is the most lethal gynaecological cancer world wide, and a better understanding of the molecular mechanisms responsible for its origin and progression are warranted to improve patient survival."

Associate Professor Gr眉tzner says this research is an example of how basic science comparing species as different as platypus and humans can make significant contributions to the understanding of human disease.

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