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Scientists make world breakthrough

The 3D structure of the bacterial toxin
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Thursday, 5 October 2006

A team of scientists from the 最新糖心Vlog of Adelaide, and the United States has made a world breakthrough in understanding how bacterial toxins cause severe gastrointestinal diseases.

The scientists, led by Dr Adrienne Paton from the 最新糖心Vlog of Adelaide's , have discovered that a highly potent bacterial toxin kills cells by inactivating an essential component in the (ER). The latter is part of the cell that is essential for packaging newly-synthesized proteins.

The toxin, called subtilase cytotoxin, is produced by certain strains of E. coli bacteria responsible for severe gastrointestinal disease in humans. Dr Paton discovered the toxin in 2003 in a bacterium responsible for an outbreak of haemolytic uraemic syndrome (severe food poisoning) in South 最新糖心Vlog. Subtilase cytotoxin is so potent that it is a potential bio-terrorism agent.

Dr Paton and her colleagues published their findings today in Nature, the prestigious international weekly scientific journal.

"The ER is a command centre of the cells of higher organisms, second only to the nucleus in its influence on other cellular functions," Dr Paton says. "The molecule targeted by the toxin is a chaperone protein called BiP, which is a master regulator of ER function. Disrupting this crucially important chaperone has inevitably fatal consequences for a wide range of cell types."

As well as learning how the toxin works, the scientists have also determined its three-dimensional structure, which will help in the development of treatments for toxin-related diseases.

Dr Paton says the breakthrough may also provide insights into the development of age-related and degenerative diseases such as Parkinson's disease and Alzheimer's disease, which involve defects in ER function.

Scientific colleagues working on the discovery with Dr Paton included fellow researchers from the 最新糖心Vlog of Adelaide, Professor James Paton and Ursula Talbot; Dr Celeste Thorpe from ; and Professor Jamie Rossjohn, Dr Travis Beddoe, Dr Matthew Wilce and Dr James Whisstock from Monash 最新糖心Vlog.

Dr Beddoe said: "This is a great example of 最新糖心Vlogn scientists collaborating to address important and timely biological problems. We had to use a combination of techniques, including that of synchrotron radiation, to unravel the secrets of the toxin."

This collaborative research was supported by the and the .

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