MICRO 3007 - Infection & Immunity A (Theory) III

North Terrace Campus - Semester 1 - 2021

This advanced course examines the molecular basis of interactions of microbial pathogens with their environment and various hosts, especially those which infect humans. Bacterial pathogens of global and medical significance that will be highlighted in detail include: Streptococcus pneumonia, Salmonella sp., Shigella sp., Staphylococcus sp., Mycobacterium; and Neisseria sp. Particular emphasis is given to the use of molecular biological approaches for study of bacterial infectious disease pathogenesis, and biotechnological applications, including vaccine development will also be highlighted. Topics to be explored include: bacterial pathogens - global significance of infectious disease; principal approaches for investigating host-pathogen interactions; the role of innate immunity and defence mechanisms; the microbiota; virulence factors which promote colonisation and damage to the host; cell surface polysaccharides and proteins; role of antigenic and phase variation in virulence and disease; gene regulation, especially in relation to expression of virulence factors; stress responses; invasion and intracellular survival and multiplication; resistance and avoidance of innate host defences; bacterial toxins; antibiotic resistance; vaccines and therapeutic interventions; genomic approaches to analysis of virulence; parasites including malaria and viruses. The lecture program is complemented by tutorials, which extend skills in exploring and critically assessing the scientific literature, and practicals which develop advanced experimental skills for the study of bacterial pathogenic mechanisms.

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Course Details

Course Code	MICRO 3007
Course	Infection & Immunity A (Theory) III
Coordinating Unit	School of Biological Sciences
Term	Semester 1
Level	Undergraduate
Location/s	North Terrace Campus
Units	3
Contact	3 x 1 hour lectures per week, 1 x 2 hour tutorials/workshops per fortnight
Available for Study Abroad and Exchange	Y
Prerequisites	MICRO 2500 or MICRO 2504 or equivalent
Incompatible	MICRO 3001, MICRO 3102
Assessment	Tutorials, problem solving questions, final exam

Course Staff

Course Coordinator: Associate Professor Renato Morona

Course Timetable

The full timetable of all activities for this course can be accessed from .

Learning Outcomes

Course Learning Outcomes

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Learning & Teaching Activities

Learning & Teaching Modes

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Workload

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Learning Activities Summary

Week Type of learning activity Topic

1 Lectures Bacteria-host interactions and innate defences

2 Lectures Bacteria-host interactions and innate defences;
Gut pathogens; Intracellular bacterial pathogens

Tutorial Critical thinking and analysis of primary research papers related to lecture material

3 Lectures Intracellular bacterial pathogens
Bacteria and subversion of host cell biology

4 Lectures Cell surface polysaccharides
Gene regulation and the host environment

Tutorial Critical thinking and analysis of primary research papers related to lecture material

5 Lectures Antibiotics

6 Lectures Vaccines
Tutorial Critical thinking and analysis of primary research papers related to lecture material

7 Lecture Microbiota, Streptococus

8 Lectures Stress responses

Tutorial Critical thinking and analysis of primary research papers related to lecture material, including problem solving questions workshop

9 Lectures Mucosal, skin, and respiratory tract pathogens

10 Lecture Respiratory tract pathogens; Gene expression in vivo

Tutorial Critical thinking and analysis of primary research papers related to lecture material, including problem solving questions workshop

11 Lecture Parasites: Viruses

12 Lecture Parasites: Viruses and Malaria

13 Problem solving questions assignment

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Assessment must encourage and reinforce learning.
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Assessment Summary

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Assessment Detail

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Submission

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Course Grading

Grades for your performance in this course will be awarded in accordance with the following scheme:

M10 (Coursework Mark Scheme)
Grade	Mark	Description
FNS		Fail No Submission
F	1-49	Fail
P	50-64	Pass
C	65-74	Credit
D	75-84	Distinction
HD	85-100	High Distinction
CN		Continuing
NFE		No Formal Examination
RP		Result Pending

Further details of the grades/results can be obtained from Examinations.

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