BIOCHEM 3235 - Cancer, Stem Cells & Development III (Biomed Sc)

North Terrace Campus - Semester 2 - 2023

This Capstone course combines lectures and tutorials with cutting edge research-based practical exercises. The lecture material covers major conceptual and technical advances in this field, focussing on two principle themes: 1. Molecular Basis of Cancer: topics include the molecular mechanisms of cell-cell communication, signal transduction pathways, genetic mutations, oncogenes and tumour suppressor genes, clonal selection, the hallmarks of cancer and metastasis, dysregulation of cell cycle checkpoints, DNA damage, replicative senescence, telomere shortening and genomic instability, control of cell proliferation and apoptosis, cancer-specific metabolism and oncometabolites. Specific examples are included of current of diagnostic and therapeutic approaches for cancer. 2. Stem Cells and Development: topics include the embryonic and adult stem cells, cellular reprogramming and induced pluripotent stem cells (iPS), generation of transgenic/knock-out mice using CRISPR/Cas9 and other techniques, with medical and other applications. Finally, the topics of cell differentiation, neurogenesis and exploring neural circuits will be covered. The practical component involves a research-based practical project using CRISPR/Cas9 technology in the first seven weeks of the semester to complement the lecture material, with problem-based learning exercises where theoretical knowledge is applied to solve practical biomedical problems in the final five weeks of the semester.

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Course Details

Course Code	BIOCHEM 3235
Course	Cancer, Stem Cells & Development III (Biomed Sc)
Coordinating Unit	School of Biological Sciences
Term	Semester 2
Level	Undergraduate
Location/s	North Terrace Campus
Units	6
Contact	3 x 1 hour lectures per week, 1 x 1 hour tutorial per week, 3 x 5 hour practical per fortnight or PBL for the semester (total 11.5 hrs/week)
Available for Study Abroad and Exchange	N
Prerequisites	BIOCHEM 2500 & BIOCHEM 2501
Incompatible	BIOCHEM 3001, BIOCHEM 3520
Restrictions	Available to BSc (Biomedical Science) students only
Assessment	Exam on lecture material, practical reports, PBL/Tutorial exercises and online assessment

Course Staff

Course Coordinator: Associate Professor Dan Peet

Course Timetable

The full timetable of all activities for this course can be accessed from .

Course Learning Outcomes

1	Understand key theoretical aspects of the regulation of cellular signalling, proliferation and differentiation in the context of embryonic development, stem cells and diseases such as cancer.
2	Understand and apply advanced experimental techniques required to solve specific biochemical problems, and understand of the ethical implications of this research.
3	Plan, perform, interpret, and quantitatively analyse biomedical research using a variety of modern experimental techniques
4	Find, interpret and critically analyse relevant scientific literature and apply it to specific problems in biomedical research.
5	Work in teams and communicate scientific outcomes

最新糖心Vlog Graduate Attribute	Course Learning Outcome(s)
Attribute 1: Deep discipline knowledge and intellectual breadth Graduates have comprehensive knowledge and understanding of their subject area, the ability to engage with different traditions of thought, and the ability to apply their knowledge in practice including in multi-disciplinary or multi-professional contexts.	1, 2, 3
Attribute 2: Creative and critical thinking, and problem solving Graduates are effective problems-solvers, able to apply critical, creative and evidence-based thinking to conceive innovative responses to future challenges.	3, 4, 5
Attribute 3: Teamwork and communication skills Graduates convey ideas and information effectively to a range of audiences for a variety of purposes and contribute in a positive and collaborative manner to achieving common goals.	4, 5, 6
Attribute 4: Professionalism and leadership readiness Graduates engage in professional behaviour and have the potential to be entrepreneurial and take leadership roles in their chosen occupations or careers and communities.	5, 6
Attribute 5: Intercultural and ethical competency Graduates are responsible and effective global citizens whose personal values and practices are consistent with their roles as responsible members of society.	6
Attribute 7: Digital capabilities Graduates are well prepared for living, learning and working in a digital society.	3, 4, 5
Attribute 8: Self-awareness and emotional intelligence Graduates are self-aware and reflective; they are flexible and resilient and have the capacity to accept and give constructive feedback; they act with integrity and take responsibility for their actions.	4, 6

Learning & Teaching Modes

This course will be delivered by the following means:

3 Lectures of 1 hour each per week.

1 Tutorial of 1 hour per week developing material covered in lectures. The lecturer takes the tutorial classes for their section.

1 Practical of 15 hours per fortnight. (Odd weeks = 5 hours & Even weeks = 10 hour duration) in the first seven weeks of the semester.

The stacked / same time teaching components are the lectures, tutorials and practicals timetabled with the existing course, Cancer, Stem Cells and Development III (BIOCHEM 3001).9

PBL/Tutorial sessions of 5 hours in the final five weeks of the semester (practical timetable).

3 online multiple choice tests of 1 hour duration per semester (weeks 5, 9 and 12, with immediate feedback provided).

Workload

The information below is provided as a guide to assist students in engaging appropriately with the course requirements.

A student enrolled in a 6 unit course, such as this, should expect to spend, on average 24 hours per week on the studies required. This includes both the formal contact time required to the course (e.g., lectures and practicals), as well as non-contact time (e.g., reading and revision).

Learning Activities Summary

Schedule
Week 1	Mechanisms of Epigenetic Cellular Memory	Lecture
Week 2	Cell Signalling Pathways	Lecture
Week 3	Signalling Domains: Structure and Function	Lecture
Week 4	Signalling Domains: Structure and Function	Lecture
Week 5	Cancer and metabolism	Lecture
Week 6	Cancer molecular biology	Lecture
Week 7	Cancer molecular biology	Lecture
Week 8	mTOR signalling in cancer	Lecture
Week 9	Cancer, the immune system and immunotherapy	Lecture
Week 10	Stem cells/CRISPR technology	Lecture
Week 11	Cell Differentiation/Neurogenesis	Lecture
Week 12	In vitro production of neurons and exploring neuronal circuits	Lecture

The 最新糖心Vlog's policy on Assessment for Coursework Programs is based on the following four principles:

Assessment must encourage and reinforce learning.
Assessment must enable robust and fair judgements about student performance.
Assessment practices must be fair and equitable to students and give them the opportunity to demonstrate what they have learned.
Assessment must maintain academic standards.

Assessment Summary

Assessment Task	Task Type	Due	Weighting	Learning Outcome
Online practical exercise	Summative	Week 4	6%	3, 4, 5
Online MCQ	Formative/summative	Week 5	1.7%	1, 2
Written test on lecture material	Summative	Week 6	20%	1, 2, 3
Practical report	Summative	Week 7	12%	3, 4, 5
Online MCQ	Formative/summative	Week 9	1.7%	1, 2
Problem - based learning exercises	Formative/summative	Week 12	12%	2, 4, 5
Online MCQ	Summative/formative	Week 12	1.7%	1, 2
Written exam on lecture material	Summative	Week 14	45%	1,2, 3

Assessment Detail

Online practical exercise (6% of total course grade): Design of tools for CRISPR, including gRNAs, PCR primers, antibodies etc. during allotted practical sessions.

Mid-semester test (20% of total course grade): A 1 hour written test held in week 6, covering the first 4 weeks of lecture material, short and long answer type questions.

Online multiple choice quizzes (5% of total course grade): Three multiple choice tests in weeks 5, 9 and 12 . Encourages revision of the material soon after the relevant lectures, and immediate feedbackprovided to students.

Practical performance and report (12% of total course grade): The seven week long practical exercise will include experimental work, keeping an up to date laboratory notebook, and a final poster presentation in week 7.
Outstanding students may have the option of a laboratory-based research project in place of the practical exercise.

Problem-based learniong exercise (12% of total course grade): Students will complete problem-based learning exercises, using current research problems in biomedical research, with small group oral presentations for assessment.

End of semester written exam: (45% of total course grade) – 2.5 hour written examination covering the

lecture material, short and long answer type questions.

Submission

If an extension is not applied for, or not granted,then a penalty for late submission
will apply. A penalty of 10% of the value of the assignment for each calendar day that the assignment is late (i.e. weekends count as 2 days), up to a maximum of 50% of the available marks will be applied. This means that an assignment that is 5 days late or more without an approved extension can only receive a maximum of 50% of the marks available for that assignment.

Course Grading

Grades for your performance in this course will be awarded in accordance with the following scheme:

M10 (Coursework Mark Scheme)
Grade	Mark	Description
FNS		Fail No Submission
F	1-49	Fail
P	50-64	Pass
C	65-74	Credit
D	75-84	Distinction
HD	85-100	High Distinction
CN		Continuing
NFE		No Formal Examination
RP		Result Pending

Further details of the grades/results can be obtained from Examinations.

Grade Descriptors are available which provide a general guide to the standard of work that is expected at each grade level. More information at Assessment for Coursework Programs.

Final results for this course will be made available through .

Student Feedback

The 最新糖心Vlog places a high priority on approaches to learning and teaching that enhance the student experience. Feedback is sought from students in a variety of ways including on-going engagement with staff, the use of online discussion boards and the use of Student Experience of Learning and Teaching (SELT) surveys as well as GOS surveys and Program reviews.

SELTs are an important source of information to inform individual teaching practice, decisions about teaching duties, and course and program curriculum design. They enable the 最新糖心Vlog to assess how effectively its learning environments and teaching practices facilitate student engagement and learning outcomes. Under the current SELT Policy (http://www.adelaide.edu.au/policies/101/) course SELTs are mandated and must be conducted at the conclusion of each term/semester/trimester for every course offering. Feedback on issues raised through course SELT surveys is made available to enrolled students through various resources (e.g. MyUni). In addition aggregated course SELT data is available.

Provision of Feedback to Students
The assessor usually provides appropriate feedback of assessment tasks to the student by means of
written comments. The student has the opportunity to directly liaise with the assessor to obtain additional feedback and clarification if required.
Student Support
Policies & Guidelines
This section contains links to relevant assessment-related policies and guidelines - all university policies.
Fraud Awareness

Students are reminded that in order to maintain the academic integrity of all programs and courses, the university has a zero-tolerance approach to students offering money or significant value goods or services to any staff member who is involved in their teaching or assessment. Students offering lecturers or tutors or professional staff anything more than a small token of appreciation is totally unacceptable, in any circumstances. Staff members are obliged to report all such incidents to their supervisor/manager, who will refer them for action under the university's student鈥檚 disciplinary procedures.

The 最新糖心Vlog of Adelaide is committed to regular reviews of the courses and programs it offers to students. The 最新糖心Vlog of Adelaide therefore reserves the right to discontinue or vary programs and courses without notice. Please read the important information contained in the disclaimer.

Authorised by:	Deputy Vice-Chancellor and Vice-President (Academic)
Maintained by:	Course Outlines Administrator

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