BIOCHEM 3000 - Molecular and Structural Biology III

North Terrace Campus - Semester 1 - 2014

This course aims to extend the discussions of protein structure and function presented in the Biochemistry Level II courses and to use this knowledge to gain an understanding of some of the essential processes of molecular biology. The course covers two principle themes: Protein Structure and Function: topics include - structure and function of different classes of proteins, protein folding, targeted protein degradation, the development of new therapies, molecular interactions and recognition. The Control of Gene Expression: topics include; genetic circuits and synthetic biology; chromatin structure and its remodelling during transcription; the recruitment and assembly of transcription factors and the RNA polymerase complex on a gene promoter; artificially manipulating gene expression with the use of "designer genes" and synthetic transcription factors; eukaryote mRNA synthesis, processing, modification, stability and translation, and manipulation of these processes to effect selective gene expression. This course combines lectures and tutorials with cutting edge research-based practical exercises to complement the lecture material.

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Course Details

Course Code	BIOCHEM 3000
Course	Molecular and Structural Biology III
Coordinating Unit	School of Molecular and Biomedical Sci(Inactive)
Term	Semester 1
Level	Undergraduate
Location/s	North Terrace Campus
Units	6
Contact	Up to 14 hours per week
Prerequisites	BIOCHEM 2500 & BIOCHEM 2501 or BIOCHEM 2504 & BIOCHEM 2505 or BIOCHEM 2502
Assessment	Exam on lecture material, practical reports and online assessments

Course Staff

Course Coordinator: Dr Tony Fratini

Course Timetable

The full timetable of all activities for this course can be accessed from .

Course Learning Outcomes

1	Understanding aspects of protein structure and function including protein folding, degradation, development of new therapies, molecular interactions and recognition.
2	Understanding aspects of the control of gene expression including genetic circuits, chromatin structure and remodelling, gene promoter assembly, eukaryotic mRNA synthesis, processing and translation.
3	Understanding key experimental processes required to evaluate protein structure, function and gene expression, and knowledge of how to apply them to solve specific biochemical problems.
4	Specific skills in planning, performing, interpreting, quantitatively analysing and communicating biochemical research using a variety of modern experimental techniques.
5	Ability to find, read, interpret and critically analyse relevant scientific literature.
6	Ability to work in teams and communicate scientific outcomes.

最新糖心Vlog Graduate Attribute	Course Learning Outcome(s)
Knowledge and understanding of the content and techniques of a chosen discipline at advanced levels that are internationally recognised.	1, 2, 3
The ability to locate, analyse, evaluate and synthesise information from a wide variety of sources in a planned and timely manner.	3, 4, 5
An ability to apply effective, creative and innovative solutions, both independently and cooperatively, to current and future problems.	4, 5, 6
Skills of a high order in interpersonal understanding, teamwork and communication.	6
A proficiency in the appropriate use of contemporary technologies.	1, 2, 3, 4
A commitment to continuous learning and the capacity to maintain intellectual curiosity throughout life.	3, 4, 5, 6
A commitment to the highest standards of professional endeavour and the ability to take a leadership role in the community.	5, 6
An awareness of ethical, social and cultural issues within a global context and their importance in the exercise of professional skills and responsibilities.	4, 6

Learning & Teaching Modes

This course will be delivered by the following means:

3 Lectures of 1 hour each per week by the Academic research staff.

1 Tutorial of 1 hour per week developing material covered in lectures. The lecturer takes the tutorial classes for their section.

1 Practical of 15 hours per fortnight. (Odd weeks = 5 hours & Even weeks = 10 hour
duration). Includes 2 oral presentations in weeks 6, 12/13, with immediate feedback provided.

3 online multiple choice tests of 1 hour duration per semester (weeks 4, 8 and 12, with immediate
feedback provided).

Workload

The information below is provided as a guide to assist students in engaging appropriately with the course requirements.

Type	Number of sessions	Duration of each session (hr)	Total hours
Lectures	36	1	36
Tutorials	12	1	12
Practicals	18	5	90
Exam	1	3	3

Type	Number of sessions	Expected preparation time (hr)	Total hours
Laboratory report	2	5	10
Presentation	2	2	4
Summative Tests	3	1	3

Type	Number of sessions	Expected preparation time (hr)	Total hours
Weekly reading	36	2	72
Tutorial preparation	12	1	12
Practical preparation	15	1	15
Test preparation	3	2	6
Exam preparation	1	48	48

Learning Activities Summary

Schedule Week	Topic	Lecture
1	Protein Life Cycle	Lecture
2	Introduction to Macromolecular X-ray Crystallography	Lecture
3	Applications of Structural Biology	Lecture
4	Protein-nucleic Acid Interactions	Lecture
5	Genetic Circuts and Synthetic Biology	Lecture
6	Proteomics	Lecture
7	Chromatin Remodelling and Transcriptional Control	Lecture
8	Chromatin Remodelling and Transcriptional Control	Lecture
9	How Transcription Factors are Regulated to Control Complex Promoters	Lecture
10	How Transcription Factors are Regulated to Control Complex Promoters	Lecture
11	RNA Processing	Lecture
12	RNA Processing	Lecture

The 最新糖心Vlog's policy on Assessment for Coursework Programs is based on the following four principles:

Assessment must encourage and reinforce learning.
Assessment must enable robust and fair judgements about student performance.
Assessment practices must be fair and equitable to students and give them the opportunity to demonstrate what they have learned.
Assessment must maintain academic standards.

Assessment Summary

Assessment Task	Task Type	Due	Weighting	Learning Outcome
Written exam on lecture material	Summative	examination week	65%	1, 2, 3
Practical write up on research project	Formative and Summative	week 6 and 12	30%	4, 5
Online assessments	Formative and Summative	weeks 4, 8 and 12	5%	1, 2, 3

Assessment Related Requirements

Attendance and active participation at all practicals is mandatory.

Assessment Detail

End of term Exam (65% of total course grade): A 3 hour examination covering the lecture material. It is made up of short and long answer type questions.

Practical (30% of total course grade): The semester long practical exercise will include experimental work, keeping an up to date laboratory notebook, 2 oral presentations and the submission of a final
practical report. The two oral presentations are each 10-15 minutes, cover the research performed in the practical, and performed in small groups in weeks 6, 12/13. Students receive feedback throughout the semester on laboratory performance and keeping of laboratory notebooks immediately after each oral presentation, and on the final report. Outstanding students may have the option of a laboratory-based research project in place of the practical exercise.

Online exercises: Three multiple choice tests in weeks 4, 8 and 12 (5% of total course grade). Encourages revision of the material soon after the relevant lectures and immediate feedback provided to students. This is done outside of contact time.

Submission

No information currently available.

Course Grading

Grades for your performance in this course will be awarded in accordance with the following scheme:

M10 (Coursework Mark Scheme)
Grade	Mark	Description
FNS		Fail No Submission
F	1-49	Fail
P	50-64	Pass
C	65-74	Credit
D	75-84	Distinction
HD	85-100	High Distinction
CN		Continuing
NFE		No Formal Examination
RP		Result Pending

Further details of the grades/results can be obtained from Examinations.

Grade Descriptors are available which provide a general guide to the standard of work that is expected at each grade level. More information at Assessment for Coursework Programs.

Final results for this course will be made available through .

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Provision of Feedback to Students

The assessor usually provides appropriate feedback of assessment tasks to the student by means of written comments. The student has the opportunity to directly liaise with the assessor to obtain additional feedback and clarification if required.
Student Support
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